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BPC 157, also known as Pentadecapeptide, consists of 15 amino acids and is a partial sequence of the body protection compound (BPC) found and isolated from human gastric juice. Through experiments, it has been shown to speed up healing and reduce pain in various wounds and damaged areas. When administered intraperitoneally or locally, it promotes faster muscle healing, complete restoration of function, and improved muscle healing even in the presence of systemic corticosteroid treatment. BPC 157 also has positive effects on gastric ulcers and lesions, triggers a vascular response for ligament and tendon healing, and enhances bone, wound, and muscle healing.
To enhance its effectiveness, BPC 157 can be combined with Growth Hormone. “When growth hormone is added to BPC 157-treated tendon fibroblasts, cell proliferation increases in a dose- and time-dependent manner, as evidenced by MTT assay and PCNA expression by RT/real-time PCR.”
BPC 157 functions during the proliferation and repair phase of wound healing. It enhances cell migration and increases cell survival rate under oxidative stress.
Phase 1: Inflammatory Phase – The inflammatory phase is the body’s initial response to stabilize a wound. During this phase, blood vessels constrict and form a clot to stop bleeding. Once blood flow ceases, blood vessels dilate to allow essential cells into the wounded area, promoting wound healing and preventing infection. This phase lasts for 1-5 days and is accompanied by pain, swelling, heat, and redness.
Phase 2: Proliferation and Repair Phase – In this phase, the wound is reconstructed through cell migration, attracting healthy cells to the injured site. Healthy granulation tissue (new connective tissue) and new blood vessels are formed through angiogenesis, which requires sufficient oxygen and nutrients. BPC 157 accelerates the growth of granulation tissue by improving cell migration and increasing cell survival rate under oxidative stress. This leads to faster angiogenesis.
Phase 3: Remodeling Maturation Phase – The final phase occurs once the wound has closed. Collagen remodeling takes place, transitioning from type III to type I. Cells that were used for wound repair but are no longer needed undergo apoptosis, or programmed cell death. Remodeling typically begins after the wound closure.
Note: The information provided is for educational purposes only and should not be considered medical advice. Please consult a healthcare professional for personalized guidance.
