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BPC 157 Pentadecapeptide “Healing Peptide”

“BPC-157: The Healing Peptide ‘Wolverine’ Explained”

BPC 157, also known as Pentadecapeptide, consists of 15 amino acids and is a partial sequence of the body protection compound (BPC) found and isolated from human gastric juice. Through experiments, it has been shown to speed up healing and reduce pain in various wounds and damaged areas. When administered intraperitoneally or locally, it promotes faster muscle healing, complete restoration of function, and improved muscle healing even in the presence of systemic corticosteroid treatment. BPC 157 also has positive effects on gastric ulcers and lesions, triggers a vascular response for ligament and tendon healing, and enhances bone, wound, and muscle healing.

To enhance its effectiveness, BPC 157 can be combined with Growth Hormone. “When growth hormone is added to BPC 157-treated tendon fibroblasts, cell proliferation increases in a dose- and time-dependent manner, as evidenced by MTT assay and PCNA expression by RT/real-time PCR.”

What is the Scientific Basis Behind the Healing Power of BPC-157?

BPC 157 functions during the proliferation and repair phase of wound healing. It enhances cell migration and increases cell survival rate under oxidative stress.

Phase 1: Inflammatory Phase – The inflammatory phase is the body’s initial response to stabilize a wound. During this phase, blood vessels constrict and form a clot to stop bleeding. Once blood flow ceases, blood vessels dilate to allow essential cells into the wounded area, promoting wound healing and preventing infection. This phase lasts for 1-5 days and is accompanied by pain, swelling, heat, and redness.

Phase 2: Proliferation and Repair Phase – In this phase, the wound is reconstructed through cell migration, attracting healthy cells to the injured site. Healthy granulation tissue (new connective tissue) and new blood vessels are formed through angiogenesis, which requires sufficient oxygen and nutrients. BPC 157 accelerates the growth of granulation tissue by improving cell migration and increasing cell survival rate under oxidative stress. This leads to faster angiogenesis.

Phase 3: Remodeling Maturation Phase – The final phase occurs once the wound has closed. Collagen remodeling takes place, transitioning from type III to type I. Cells that were used for wound repair but are no longer needed undergo apoptosis, or programmed cell death. Remodeling typically begins after the wound closure.

Note: The information provided is for educational purposes only and should not be considered medical advice. Please consult a healthcare professional for personalized guidance.

What Type of Healing Does BPC 157 Promote?

  • Tendon-to-bone healing
  • Healing of damaged ligaments
  • Muscle Sprains, tears, and damage –  it has completely reversed systemic corticosteroid-impaired muscle healing.
  • Skin Burns
  • Protect organs and to prevent ulcers of the stomach.
  • It relieves inflammation
  • Promotes outgrowth of tendon fibroblasts
  • Improves digestive function
  • Protests and heals inflamed intestinal epithelium (leaky gut)
  • Improves inflammatory bowel disease
  • Protest liver from toxic insults (alcohol, antiboitoics, etc.) and promotes healing
  • It heals soft tissue

Available Research / Source on BPC 157 

  • Stable gastric pentadecapeptide BPC 157 is an antiulcer peptidergic agent, safe in inflammatory bowel disease clinical trials and wound healing, stable in human gastric juice and has no reported toxicity. Notably, it has a prominent effect on alcohol lesions (i.e., acute, chronic) and NSAIDs-lesions (interestingly, BPC 157 both prevents and reverses arthritis) and acts as a free radical scavenger and exhibits neuroprotective properties.
  • (Sikiric, P., et al., Stable Gastric Pentadecapeptide BPC 157: Novel Therapy in Gastrointestinal Tract. CPD, 2011. 17(16): p. 1612-1632.)
  • Chang CH , et al. (n.d.). The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. – PubMed – NCBI. National Center for Biotechnology Information.
  • Chang CH , et al. (n.d.). Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. – PubMed – NCBI. National Center for Biotechnology Information.
  • GwyerD , et al. (n.d.). Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. – PubMed – NCBI. National Center for Biotechnology Information.
  • PevecD , et al. (n.d.). Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application. – PubMed – NCBI. National Center for Biotechnology Information.

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